Selected Publications
Turcato FC, Wegman E, Lu T, Ferguson N, Luo Y. Dopaminergic neurons are not a major Sonic hedgehog ligand source for striatal cholinergic or PV interneurons. iScience. 2022 Oct 7;25(11):105278. doi: 10.1016/j.isci.2022.105278. PMCID: PMC9587326.
Fucheng Luo, Jiapeng Wang, Zhen Zhang, Zhen You, Alicia Bedolla, FearGod Okwubido-Williams, L. Frank Huang, Jerry Silver, Yu Luo. Inhibition of CSPG receptor PTPσ promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke. Cell Reports. 40(4) July, 2022. https://doi.org/10.1016/j.celrep.2022.111137
Ware K, Wegman E, Bedolla A, Luo Y. Major Caveats Discovered in the Genetic Cell Ablation Model Used to Study Microglia Functions. Transl. Stroke Res. 2022. https://doi.org/10.1007/s12975-022-01029-0
Wang J, Ware K, Bedolla A, Allgire E, Turcato F, Weed M, Sah R, Luo Y. Disruption of Sonic Hedgehog Signaling Accelerates Age-Related Neurogenesis Decline and Abolishes Stroke-Induced Neurogenesis and Leads to Increased Anxiety Behavior in Stroke Mice. Transl. Stroke Res. 2022 Jan 31. https://doi.org/10.1007/s12975-022-00994-w
Bedolla A, Taranov A, Luo F, Wang J, Turcato F, Fugate EM, Greig NH, Lindquist DM, Crone SA, Goto J, Luo Y. Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of cytokine upregulation. J Neuroinflammation. 2022 Jan 4;19(1):3. doi: 10.1186/s12974-021-02367-w. PubMed PMID: 34983562; PubMed Central PMCID: PMC8728932.
Boyne P, Awosika OO, Luo Y. Mapping the corticoreticular pathway from cortex-wide anterograde axonal tracing in the mouse. J Neurosci Res. 2021 Dec;99(12):3392-3405. doi: 10.1002/jnr.24975. Epub 2021 Oct 22. PubMed PMID: 34676909; PubMed Central PMCID: PMC8714061.
Luo F, Zhang Z, Luo Y. Differential Role of p53 in Oligodendrocyte Survival in Response to Various Stresses: Experimental Autoimmune Encephalomyelitis, Cuprizone Intoxication or White Matter Stroke. Int J Mol Sci. 2021 Nov 26;22(23). doi: 10.3390/ijms222312811. PubMed PMID: 34884611; PubMed Central PMCID: PMC8658009.
Gu Y, Gao H, Kim K, Liu Y, Ramos-Estebanez C, Luo Y, Wang Y, Yu X. Dynamic oxygen-17 MRI with adaptive temporal resolution using golden-means-based 3D radial sampling. Magn Reson Med. 2021 Jun;85(6):3112-3124. doi: 10.1002/mrm.28636. Epub 2020 Dec 25. PubMed PMID: 33368649; PubMed Central PMCID: PMC8324328.
Luo F, Zhang Z, Barnett A, Bellinger TJ, Turcato F, Schmidt K, Luo Y. Cuprizone-induced demyelination under physiological and post-stroke condition leads to decreased neurogenesis response in adult mouse brain. Exp Neurol. 2020 Apr;326:113168. doi: 10.1016/j.expneurol.2019.113168. Epub 2020 Jan 2. Review. PubMed PMID: 31904386.
Hu D, Sun X, Liao X, Zhang X, Zarabi S, Schimmer A, Hong Y, Ford C, Luo Y, Qi X. Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathol. 2019 Jun;137(6):939-960. doi: 10.1007/s00401-019-01993-2. Epub 2019 Mar 15. PubMed PMID: 30877431; PubMed Central PMCID: PMC6531426.
Glotfelty EJ, Delgado T, Tovar-Y-Romo LB, Luo Y, Hoffer B, Olson L, Karlsson T, Mattson MP, Harvey B, Tweedie D, Li Y, Greig NH. Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury. ACS Pharmacol Transl Sci. 2019 Apr 12;2(2):66-91. doi: 10.1021/acsptsci.9b00003. Epub 2019 Feb 11. PubMed PMID: 31396586; PubMed Central PMCID: PMC6687335.
Hsueh, Shih-Chang; Chen, Kai-Yun; Lai, Jing-Huei; Wu, Chung-Che; Yu, Yu-Wen; Luo, Yu; Hsieh, Tsung-Hsun; Chiang, Yung-Hsiao (2018. ) Voluntary Physical Exercise Improves Subsequent Motor and Cognitive Impairments in a Rat Model of Parkinson's Disease.International journal of molecular sciences, , 19 (2 )
Kim, Dong Seok; Choi, Ho-Il; Wang, Yun; Luo, Yu; Hoffer, Barry J; Greig, Nigel H (2017. ) A New Treatment Strategy for Parkinson's Disease through the Gut-Brain Axis: The Glucagon-Like Peptide-1 Receptor Pathway.Cell transplantation, , 26 (9 ) ,1560-1571More Information
Lu, Tao; Kim, Paul P; Greig, Nigel H; Luo, Yu (2017. ) Dopaminergic Neuron-Specific Deletion of p53 Gene Attenuates Methamphetamine Neurotoxicity.Neurotoxicity research, , 32 (2 ) ,218-230More Information
Jin, Yongming; Barnett, Austin; Zhang, Yifan; Yu, Xin; Luo, Yu (2017. ) Poststroke Sonic Hedgehog Agonist Treatment Improves Functional Recovery by Enhancing Neurogenesis and Angiogenesis.Stroke, , 48 (6 ) ,1636-1645More Information
Yang, Ling-Yu; Greig, Nigel H; Huang, Ya-Ni; Hsieh, Tsung-Hsun; Tweedie, David; Yu, Qian-Sheng; Hoffer, Barry J; Luo, Yu; Kao, Yu-Chieh; Wang, Jia-Yi (2016. ) Post-traumatic administration of the p53 inactivator pifithrin-O oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury.Neurobiology of disease, , 96 ,216-226More Information
Filichia, Emily; Hoffer, Barry; Qi, Xin; Luo, Yu (2016. ) Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP.Scientific reports, , 6 ,32656More Information
Zhou, Xiaofei; Pace, Jonathan; Filichia, Emily; Lv, Tao; Davis, Brandon; Hoffer, Barry; Selman, Warren; Luo, Yu (2016. ) Effect of the sonic hedgehog receptor smoothened on the survival and function of dopaminergic neurons.Experimental neurology, , 283 (Pt A ) ,235-45More Information
Qi, Xin; Davis, Brandon; Chiang, Yung-Hsiao; Filichia, Emily; Barnett, Austin; Greig, Nigel H; Hoffer, Barry; Luo, Yu (2016. ) Dopaminergic neuron-specific deletion of p53 gene is neuroprotective in an experimental Parkinson's disease model.Journal of neurochemistry, , 138 (5 ) ,746-57More Information
Guo, Xing; Sun, XiaoYan; Hu, Di; Wang, Ya-Juan; Fujioka, Hisashi; Vyas, Rajan; Chakrapani, Sudha; Joshi, Amit Umesh; Luo, Yu; Mochly-Rosen, Daria; Qi, Xin (2016. ) VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.Nature communications, , 7 ,12646More Information
Wang, Jin-Ya; Huang, Ya-Ni; Chiu, Chong-Chi; Tweedie, David; Luo, Weiming; Pick, Chaim G; Chou, Szu-Yi; Luo, Yu; Hoffer, Barry J; Greig, Nigel H; Wang, Jia-Yi (2016. ) Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat.Journal of neuroinflammation, , 13 (1 ) ,168More Information
Sheng, Yang; Filichia, Emily; Shick, Elizabeth; Preston, Kenzie L; Phillips, Karran A; Cooperman, Leslie; Lin, Zhicheng; Tesar, Paul; Hoffer, Barry; Luo, Yu (2016. ) Using iPSC-derived human DA neurons from opioid-dependent subjects to study dopamine dynamics.Brain and behavior, , 6 (8 ) ,e00491More Information
Sheng, Yang; Filichia, Emily; Shick, Elizabeth; Preston, Kenzie L; Phillips, Karran A; Cooperman, Leslie; Lin, Zhicheng; Tesar, Paul; Hoffer, Barry J; Luo, Yu (2016. ) Lower Dopamine D2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs.The American journal of psychiatry, , 173 (4 ) ,429-31More Information
Liu, H-S; Shen, H; Luo, Y; Hoffer, B J; Wang, Y; Yang, Y (2016. ) Post-treatment with cocaine- and amphetamine-regulated transcript enhances infarct resolution, reinnervation, and angiogenesis in stroke rats - an MRI study.NMR in biomedicine, , 29 (3 ) ,361-70More Information
Luo, Yu; Hoffer, Alan; Hoffer, Barry; Qi, Xin (2015. ) Mitochondria: A Therapeutic Target for Parkinson's Disease?.International journal of molecular sciences, , 16 (9 ) ,20704-30More Information
Yu Luo, Hui Shen, Hua‐Shan Liu, Seong‐Jin Yu, David Reiner, Brandon K. Harvey, Barry J. Hoffer, Yihong Yang, and Yun Wang (2013. ) CART peptide induces neuroregeneration in stroke rats .Journal of Cerebral Blood Flow and Metabolism , , 33 (2 ) ,300-10
Filichia, E; Shen, H; Zhou, X; Qi, X; Jin, K; Greig, N; Hoffer, B; Luo, Y (2015. ) Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model.Neuroscience, , 295 ,1-10More Information
Yu Luo, Chi-Chung Kuo, Hui Shen, Jenny Chou, Nigel H. Greig, Barry J. Hoffer, Yun Wang (2009. ) Delayed treatment with a p53 inhibitor enhances functional recovery in stroke brain .Ann Neurol, , 65 (5 ) ,520-30
Jin, Yongmin; Raviv, Nataly; Barnett, Austin; Bambakidis, Nicholas C; Filichia, Emily; Luo, Yu (2015. ) The shh signaling pathway is upregulated in multiple cell types in cortical ischemia and influences the outcome of stroke in an animal model.PloS one, , 10 (4 ) ,e0124657More Information
Yu Luo, Feng Xing, Rita Guiliano, Howard J. Federoff (2008. ) Identification of a novel Nurr1 interacting protein .J Neurosci, , 28 (37 ) , 9277-86
Yu Luo, Leigh A. Henricksen, Rita E. Giuliano, Landa Prifti, Linda M. Callahan and Howard J. Federoff (2007. ) VIP is a transcriptional target of Nurr1 in dopaminergic cells .Experimental Neurology, , 203 (1 ) ,221-232
Gu, Yuning; Gao, Huiyun; Kim, Kihwan; Liu, Yuchi; Ramos-Estebanez, Ciro; Luo, Yu; Wang, Yunmei; Yu, Xin (2021. ) Dynamic oxygen-17 MRI with adaptive temporal resolution using golden-means-based 3D radial sampling.Magnetic resonance in medicine, , 85 (6 ) ,3112-3124More Information
Luo, Fucheng; Zhang, Zhen; Barnett, Austin; Bellinger, Tania J; Turcato, Flavia; Schmidt, Kelly; Luo, Yu (2020. ) Cuprizone-induced demyelination under physiological and post-stroke condition leads to decreased neurogenesis response in adult mouse brain.Experimental neurology, , 326 ,113168More Information
Flavia Turcato, Paul Kim, Austin Barnett, Yongming Jin, Mike Scerba, Anthony Casey, Warren Selman, Nigel H. Greig, and Yu Luo (2018. ) Sequential combined Treatment of Pifithrin-α and Posiphen Enhances Neurogenesis and Functional Recovery After Stroke .Cell Transplantation, ,
Hu, Di; Sun, Xiaoyan; Liao, Xudong; Zhang, Xinwen; Zarabi, Sara; Schimmer, Aaron; Hong, Yuning; Ford, Christopher; Luo, Yu; Qi, Xin (2019. ) Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.Acta neuropathologica, , 137 (6 ) ,939-960More Information
Glotfelty, Elliot J; Delgado, Thomas; Tovar-Y-Romo, Luis B; Luo, Yu; Hoffer, Barry; Olson, Lars; Karlsson, Tobias; Mattson, Mark P; Harvey, Brandon; Tweedie, David; Li, Yazhou; Greig, Nigel H (2019. ) Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury.ACS pharmacology & translational science, , 2 (2 ) ,66-91More Information
Turcato, Flavia; Kim, Paul; Barnett, Austin; Jin, Yongming; Scerba, Mike; Casey, Anthony; Selman, Warren; Greig, Nigel H; Luo, Yu (2018. ) Sequential combined Treatment of Pifithrin-? and Posiphen Enhances Neurogenesis and Functional Recovery After Stroke.Cell transplantation, , 27 (4 ) ,607-621More Information
Chang, Cheng-Fu; Lai, Jing-Huei; Wu, John Chung-Che; Greig, Nigel H; Becker, Robert E; Luo, Yu; Chen, Yen-Hua; Kang, Shuo-Jhen; Chiang, Yung-Hsiao; Chen, Kai-Yun (2017. ) (-)-Phenserine inhibits neuronal apoptosis following ischemia/reperfusion injury.Brain research, , 1677 ,118-128More Information
Lu, Tao; Kim, Paul; Luo, Yu (2017. ) Tp53 gene mediates distinct dopaminergic neuronal damage in different dopaminergic neurotoxicant models.Neural regeneration research, , 12 (9 ) ,1413-1417More Information
Xu, Kui; Ye, Lena; Sharma, Katyayini; Jin, Yongming; Harrison, Matthew M; Caldwell, Tylor; Berthiaume, Jessica M; Luo, Yu; LaManna, Joseph C; Puchowicz, Michelle A (2017. ) Diet-Induced Ketosis Protects Against Focal Cerebral Ischemia in Mouse.Advances in experimental medicine and biology, , 977 ,205-213More Information
Wang, Jing-Ya; Huang, Ya-Ni; Chiu, Chong-Chi; Tweedie, David; Luo, Weiming; Pick, Chaim G; Chou, Szu-Yi; Luo, Yu; Hoffer, Barry J; Greig, Nigel H; Wang, Jia-Yi (2016. ) Erratum to: Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat.Journal of neuroinflammation, , 13 (1 ) ,228More Information
Tweedie, David; Fukui, Koji; Li, Yazhou; Yu, Qian-Sheng; Barak, Shani; Tamargo, Ian A; Rubovitch, Vardit; Holloway, Harold W; Lehrmann, Elin; Wood, William H; Zhang, Yongqing; Becker, Kevin G; Perez, Evelyn; Van Praag, Henriette; Luo, Yu; Hoffer, Barry J; Becker, Robert E; Pick, Chaim G; Greig, Nigel H (2016. ) Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms.PloS one, , 11 (6 ) ,e0156493More Information
Luo, Yu (2012. ) The function and mechanisms of Nurr1 action in midbrain dopaminergic neurons, from development and maintenance to survival.International review of neurobiology, , 102 ,1-22More Information
Luo, Y; Neet, K E (1992. ) The unprocessed C-terminal dipeptide of recombinant beta-nerve growth factor determines three stable forms with distinct biological activities. The Journal of biological chemistry, , 267 (17 ) ,12275-83